Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
The Synthesis of Acyclic Beta Enaminones Based on Benzidine
Author(s): Nabugomu Ronald Jowet, Hao Haijun, Zhuang Jungpeng, Zhao Shisheng, Shi Yujian(z)-4-((4-amino-[1,1’biphenyl]-4-yl)amino)pent-3-en-2-one,L3c1, (z)-5-((4’-amino-[1,1’biphenyl]-4-yl)amino)hept-4-en-3-one L3d1, (z)-3-((4’- amino-[1,1’biphenyl]-4-yl) amino)-1-phenylbut-2-en-1-one L3e1, were synthesized from the condensation of acyclic -1,3- betadiketone derivatives and Benzidine using ethanol. The presence of a linkage of two phenyl groups in the para position in relation to the amine group makes this particular class of enaminones have prospective added advantages and hence functionalization. The advantages offered by this method presented are use of mild, cheap, shorter reaction time for complete enamination and an aspect of green Chemistry.
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