Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
The In-Silico Screening of Pyrazolo[3,4-E][1,4]Thiazepine Derivatives as Potent Cytotoxic Agents
Author(s): Srikanth A, Hemanth Kumar P, Vijayakumar V, Sudha, Anand A, Sarveswari SA new series of 1, 4-thiazepinone incorporated pyrazolopyridines has been synthesized using L-proline as a catalyst through multi-component reaction which in turn subjected to the in-silico cytotoxicity studies against various cancer cell lines and almost all the compounds found to show good to moderate activity. Among the tested compounds, compound 4f and 4k are found to have le
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