Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
The influence of clathrate �Ž�² cyclodextrin with para-amino-benzoic acid and silyl group over behavioral performance of laboratory animals
Author(s): Sergievich A. A., Korolev R. A., Grachev M. K., Kurochkina G. I., Popkov A. V., Khoroshikh P. P., Batalova T. A., Chaika V. V. and Golokhvast K. SIn this work the assessment of the neurotropic activity of clathrate β-cyclodextrin withpara-amino-benzoic acid and silyl group (CD-PABA-CG) under the conditions of instrumental stress during self-defensive motivation in the universal problem-solving cameraare shown.The testing was held in 30 days in the universal problem camera on 86 non-linear white male rats. When using the new synthesized compound CD-PABA-CG in the dosage 10 mg/kg it changes positively the indicates of motivational-energetic sphere in the instrumental defensive behavior’s conditions, and it demonstrates actoprotecting feature. CD-PABA-CG have positive neurotropic effect by the example of cognitive indicate. The compound presented have a wide action spectrum and is perspective in the pharmacological area.
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Citations : 15261
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