Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
The hypoglycemic effect of oleanolic acid which extracted from Alhagi Roots in diabetic rabbits by improve antioxidant defenses
Author(s): Ali M.A. Al-KufaishiThis research include extractoleanolic acid (OAA) from Alhagi roots was administered orally to diabetic rabbits induced by alloxan once per day for one month. This treatment has been given significant decreasing of blood glucose, lipids and lipid peroxidation levels (malondiadehyde MDA). In addition, the levels of antioxidant enzymes, catalase (CAT) and superoxide dismutase (SOD) decreased in diabetic rabbits however these levels returned to normal when treated by oleanolic acid. From this results can suggest the oxidative stress plays important role in diabetes, and treatment with oleanolic acid useful in controlling not only for glucose and lipid levels, but these components may be also improvement the antioxidants potential.
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Citations : 15261
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