Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
The comparison between effects of Berberis vulgaris Extract and aerobic exercise on none-alcoholic fatty liver in male rat
Author(s): Sara Torkamaneh, Gholamreza Sharifi and Mahmoud Rafieian-KopaeiThe aim of this study was to evaluate the effects of Berberis vulgaris extract, aerobic exercise or their combination on the indicators of fatty liver, including serum C-reactive protein (CRP) and serum alanine aminotransferase (SGPT) in Wistar rats. Forty male Wistar rats were divided into 5 equal groups, including B. vulgaris extract, aerobic exercise, B. vulgaris extract combined with aerobic exercise, control and hyperlipidemic group. After blood sampling, CRP and SGPT levels were measured and the data were analyzed by ANOVA and least significance difference tests. SGPT enzyme activity in all experimental groups was reduced significantly compared with hyperlipidemic group (P<0.05). Also, the results of the CRP level in the group receiving the extract of B. vulgaris combined with aerobic exercise showed the lowest average and the largest difference with the hyperlipidemic group (P<0.05). Aerobic exercise combined with B. vulgaris extract could improve fatty liver and is beneficial in these patients.
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