Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Study of Substituent Effect and Evaluation of Biological Activities of (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ones
Author(s): Kamalakkannan D, Vanangamudi G, Thirunarayanan GIn the present study, nine number of different substituted (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one compounds were synthesized by the condensation reaction of 3,4,5-trimethoxy acetophenone with different substituted benzaldehyde in alcoholic base (sodium hydroxide in ethanol). The yields of the products have been obtained above 80%. The formations of all the (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ones have been confirmed by analytical and spectroscopic data. All the assigned spectral values of substituted (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one compounds are correlated by single and multi-correlation analyses with Hammett sigma constants and F & R parameters. From the regression analyses result, the electronic effects of the substituent were discussed. The evaluation of antimicrobial activity of synthesized chalcones has been screened using Kirby-Bauer method.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
