Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Structural Characterization, Antimicrobial Activity of Complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) With 7-((2-Aminoethyl)Amino)-5-Bromo-6-Hydroxy-1-Methylquinolin-1- Ium-3-Sulfonate
Author(s): Mai Phuong Chi, Nguyen Thi Quy and Le Thi Hong Hai*In this research, a new quinoline derivative, 7-((2-aminoethyl)amino)-5-bromo-6-hydroxy-1- methylquinolin-1-ium-3-sulfonate (QEt) as well as six complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) with this ligand [M(QEt-1H)2].nH2O (M: Co, Cu, Zn, Cd, Hg), [Ni(QEt-1H)Cl].2H2O were synthesized. The molecular formulas and structures of the complexes were determined using measurement as IR, EDX, ESI-MS, 1H NMR spectra and thermal analysis. The bioactivity tests shown that the ligand and CuQEt complex have limiting effects to microorganisms, complexes CoQEt, ZnQEt, CdQEt and HgQEt exhibit antibacterial activities with low IC50 values, from 0.5 to 56.0 μg/mL and be most effective to Bacillus subtilis. Especially HgQEt inhibits effectively to almost types of bacteria.
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