Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis, physicochemical, biological and pharmacological studies of some new 5-aminoarylamine-3-methyl-1-substituted-4-(aryliminomethyl)-pyrazoles
Author(s): Tandrima Majumder, Biplab De, Binoy Behari Goswami and Subrat KarAmination of 5-aminoarylamine-3-methyl-1-substituted pyrazole-4-carboxaldehydes with aromatic or aliphatic amines gives new 12 (13 – 24) compounds 5-aminoarylamine-3-methyl-1- substituted-4-(aryliminomethyl)-pyrazoles (13 – 24). All the newly synthesized products were characterized by the spectral studies. The Rf, pKa and Molar absorptivity studies were carried out for all the compounds. They were screened for antibacterial, analgesic and antiinflammatory studies. The pKa was correlated with the analgesic study and anti-inflammatory study and the plots were obtained.
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