Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis of Some Novel 2-S-tetra-O-benzoyl-D-glucopyranosyl-1-aryl-5-hepta-O-benzoyl-�Ž�²-D-lactosyl-2-isothiobiurets
Author(s): Kedar P. Pande and Shirish P. DeshmukhThe study of S-and N-glycosides is important in carbohydrate chemistry. Sugar isocyanate is good precursors and versatile intermediate for synthesis of S- and N-glycosides. Carbohydrates play an important role in the number of biological events and play an important role in their synthetic strategy as well. Similarly the amino sugars are an important class of glycosidase inhibitors and are arousing great interest as potential therapeutic agents. Several 2-S-tetra-Obenzoyl- D-glucopyranosyl-1-aryl-5-hepta-O-benzoyl-β-D-lactosyl-2-isothiobiurets have been synthesized for the first time by the interaction of hepta-O-benzoyl-β-D-lactosyl isocyanate and S-tetra-O-benzoyl-D-glucopyranosyl-1-aryl isothiocarbamides. All the synthesized compounds were characterized on the basis of elemental analysis and IR, 1HNMR and Mass spectral analysis. The polarimetric study of the compounds was carried out.
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