Synthesis of some new 3(4-hydroxyphenyl)prop-2-en-1-one 4-phenyl substituted schiff�?¢�?�?��?�?�s bases and their antibacterial activity

Ujwala Sawarkar; Meghasham Narule; Mahendra Chaudhary

Abstract

Synthesis of some new 3(4-hydroxyphenyl)prop-2-en-1-one 4-phenyl substituted schiff�?¢�?�?��?�?�s bases and their antibacterial activity

Author(s): Ujwala Sawarkar, Meghasham Narule, Mahendra Chaudhary

4-amino benzylidene acetophenone 1 was prepared by condensing 4-hydroxy benzaldehyde with 4-amino acetophenone. 1-(4-aminophenyl)-3-(4-hydroxyphenyl) prop-2-en-1-one react with 4-hydroxy aldehyde to give 3(4- hydroxy phenyl) prop-2-en-1-one-4-phenyl substituted Schiff’s bases 2. The structural elucidations of these compounds were done on the basis of chemical and structural data. The synthesized compound were characterized by IR, H-NMR and mass spectra. The antibacterial activity of these compounds have also been screened and found to be effective against gram +ve and gram –ve bacteria. The compounds were evaluated for antibacterial and antifungal activity by cup plate method, disc diffusion method respectively. All the compounds (2b, 2d, 2f ) at a concentration of 100, 10 and 1ug/L showed good antibacterial activity against staphylococcus aureus and bacillus subtilis and the compounds (2a, 2c, 2e, 2g) exhibited good antifungal activity against aspergillus niger.

PDF

Select your language of interest to view the total content in your interested language