Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of some arylidene derivatives of thiazolopyrimidineas anticancer
Author(s): Tawfeek Ahmed Ali Yahyaa, Jalal H. Abdullaha, Mokhtar Abd Hafiz Al-Ghorafib and Shada H. Yassina and Hassan M. AlmahbshicA series of arylidenesarylidenes(D1-10) were synthesized by reaction of the thiazolopyrimidinones(C1&C2) with the appropriate aldehyde. The arylidene derivatives (D3) and (D8) showed significant anticancer activity (IC50= 4.32 and 4.72 μg/ml respectively) when compared to standard drug doxorubicin (IC50= 3.76 μg/ml).
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Citations : 15261
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