Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of novel bioactive pyrazole carbothioamides and their antifungal activity studies
Author(s): M. Chandrashekar, A. Dileep Kumar, G. Pavithra, N. Renuka and K. Ajay KumarA series of new pyrazoline carbothioamides bearing furan moiety were synthesized by simple one pot procedure. The method involves base catalyzed cyclocondensation reaction of chalcones 1a-e and thiosemicarbazide 2 in ethanol under optimum temperature. The reaction yielded the title compounds 5-aryl-3-(furan-2-yl)-4,5-dihydro-1Hpyrazole- 1-carbothioamides 3a-e in excellent yields. The synthesized new compounds were characterized by spectral studies and elemental analysis, and were evaluated in vitro for their antifungal susceptibility
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Citations : 15261
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