Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of novel 1,2,4-triazoles and their evaluation of 5-LOX inhibition and antimicrobial activity
Author(s): Mani Palla, Mahesh Palla, Praveen Choppara and Murthy Y. L. N.A novel series of 1,2,4-triazoles were designed, synthesised and screened for their 5-LOX inhibition and antimicrobial activity. Among the tested compounds, compounds 6b and 6e showed potent 5-LOX inhibition with an IC50 of 6.98 and 8.0 μg/mL respectively, 6c and 6e were the promising compounds in antibacterial assay, where as compound 6c was found to be lead compound in antifungal assay.
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Citations : 15261
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