Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis of novel 1,2,3-triazole derivatives containing oxadiazole, trifluoromethyl pyridine
Author(s): Vijay V. Dabholkar, S. N. Gandhale, N.B. Shinde4 (trifluoromethyl) pyridine-3-carbohydrazide (4) reaction with chloroacetic acid in presence of POCl3 gave chloro methyl 1, 3, 4 –Oxadiazole (5) derivative. Compound (5) on treatment with sodium azide yielded azidiomethyl- 1, 3, 4-oxadiazole (6). This azide (6) derivative further reacted with acetyl acetone in presence of potassium carbonate to form 1, 4, 5-trisubstitued 1, 2, 3-triazole (7). On reaction of (7) with hydroxyl amine hydrochloride gave its oxime derivative (8) which on treatment with different substituted aromatic benzyl chloride offered corresponding novel 1, 4, 5-trisubstitued 1, 2, 3-triazol oxime ether derivatives (9a-c) respectively.
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