Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of Isoxazolines: Small Molecules of Potent Antimicrobial Activity
Author(s): Manjula N, Lokeshwari DM, Dileep Kumar A, Renuka N, Ajay Kumar KA simple procedure for the synthesis of isoxazole derivatives was developed. Cyclocondensation reaction of chalcones with hydroxylamine hydrochloride catalyzed by an acid produced isoxazoles in good yields. The synthesized new compounds were characterized by spectral studies and elemental analysis; before being were screened in vitro for their antimicrobial susceptibilities against different bacteria and fungi species.
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Citations : 15261
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