Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis of Isocoumarins and its derivatives
Author(s): Vijakumar L. Chavan and Rajendra R. Rane3-methyl-1-oxo-1-H-2-benzopyran-4-carboxylic acid was synthesized in excellent yields by the reaction of homophthalic anhydride with acetyl chloride using pyridine as a catalyst, followed by rearrangement of 4-acetyl- 1H-2-benzopyran-1,3(4H)-dione with Conc. Sulphuric acid. Further 3-methyl-1-oxo-1H-2-benzopyran-4-carboxylic acid was derrivatised to various isoquinolones using ammonia and respective primary amines. It was also inferred the isoquinolones obtained were same when ammonia and other primary amines were treated with 3-methyl-1-oxo- 1-H-2-benzopyran-4-carboxylic acid, 4-acetyl-1H-2-benzopyran-1,3(4H)-dione, or 3-methyl-1H-2-benzopyran-1- one.
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