Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of Carbazole-1&3-acids by using Suzuki coupling followed by Cadagon Reductive cyclization
Author(s): Janardhanreddy Kanchani and M.C.S. Subha*Using a Suzuki coupling followed by Cadagon reductive cyclization as a key steps, the first synthesis of 1-carboxylic acid carbazole has been achieved in 4 steps and in 65% overall yield. In the present work, this approach was applied to the total synthesis of carbazole alkaloids. This is the simple way to synthesise 9H-Carbazole-1-carboxylic acid and 9H-Carbazole-2-carboxylic acid.
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Citations : 15261
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