Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, molecular docking, DNA binding and biological evaluation of schiff base transition metal complexes
Author(s): M. R. Lokesh, G. Krishnamurthy, H. S. Bhojyanaik,N. D. Shashikumar, P. Murali Krishna and B. SreekanthNovel complexes of Fe(III), Co(II) and Ni(II) with Schiff base ligand 3-[(E)-(4H-1,2, 4-triazol-4- ylimino)methyl]quinoline-2-thiol (L) have been synthesized and characterized. The interaction of the complexes with calf thymus DNA (CT-DNA) was monitored by red shift and hypochromism and hyperchromism in the UV–vis spectra. The observed intrinsic binding constant (Kb) in the range 106 M−1 together with structural analysis of the complexes indicate the intercalative mode of binding. In vitro biological activities indicate that the metal complexes were more active compare to the uncoordinated ligand. The docking study revealed that metal complexes are potential inhibitors of cancer causing receptors.
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