Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis, Molecular docking and evaluation of antifungal activity of some benzyl benzimidazole derivatives
Author(s): Suvarna Katii, Preeti Bagul, Luketa Alai, Rasika Mahale, Ashok Pingle and Sanjay WaghA novel series of benzyl benzimidazoles substituted with piperazines were designed by study of active site of the fungal enzyme of cytochrome P 450 family lanosterol 14 α demethylase and synthesized. The molecular docking study of these compounds was performed at the active site of this enzyme. The synthesised compounds were charecterised by spectral analysis (IR,1H NMR).The screening of the synthesised compounds for in vitro antifungal activity revealed activity against c Candida albicans of some of the compounds comparable to that of ketoconazole.
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Citations : 15261
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