Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Hammett spectral correlation and biological evaluation of some substituted (E) 1-hydroxy-2-naphthyl chalcones
Author(s): K. Sathiyamoorthi, V. Mala, R. Suresh, S. P. Sakthinathan, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S. Vijayakumar, G. Vanangamudi* and G. ThirunarayananA series of some substituted (E)-1-(1-hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-oneshave been synthesized by microwave assisted Silica- H3PO4catalyzed green Crossed-Aldol condensation of 1-hydroxy-2-acetylenaphthone and substituted benzaldehydes. These chalcones were characterized by their physical constants and spectral data. From IR and NMR spectra, the spectral frequencies of vCOs-cis and s-trans, deformation modes of νCHip, νCHop, νCH=CHop and νC=Cop(cm-1), δH and δC of α, β and CO (ppm) of synthesized chalcones were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituents on the group frequencies have been discussed. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.
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