GET THE APP

Synthesis, Characterization, XRD Studies, Molecular Docking and Biological Screening of N-phenyl-2-(pyridin-4-ylcarbonyl) Hydrazine Carboxamide and their 3d Metal Ion Complexes | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, Characterization, XRD Studies, Molecular Docking and Biological Screening of N-phenyl-2-(pyridin-4-ylcarbonyl) Hydrazine Carboxamide and their 3d Metal Ion Complexes

Author(s): Yuvaraj TCM, Parameshwara Naik P, Krishnamurthy G, Venkatesh TV, Mohammed Shafeeulla R, Manjuraj T

A synthesis of semicarbazide derivative like N-phenyl-2-(pyridin-4-ylcarbonyl) hydrazine carboxamide by the reaction of isoniazid and phenyl isocyanate has been done, using this ligand and their 3d metal ions such as Ni II , Co II , Cu II , Zn II and Mn II complexes were synthesized. The ligand and their metal complexes have been characterized by different analytical techniques, such as elemental analyses, molar conductivity measurements, UV-Visible, Fourier Transform Infra-Red (FTIR), Proton Nuclear Magnetic Resonance ( 1 H-NMR), Carbon-13 Nuclear Magnetic Resonance ( 13 C-NMR), Liquid Chromatography–Mass Spectrometry (LCMS), Powder X-ray Diffraction (PXRD) and Thermo Gravemetric Analysis (TGA) studies. The antioxidant, antimicrobial and antifungal activity of these compounds reported agreeable results against bacterial strains and fungal strains. The molecular docking studies for synthesized complexes exhibited excellent binding energy interaction with protein enzymes.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry