Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization, theoretical study and antibacterial studies of N(4- substitution phenylcarbamothioyl)biphenyl-4 carboxmide derivatives
Author(s): Hanan A. AL-hazam, Abas Fadhel and Hyder Abeduljaleel RhadiNew compounds of N(4-substitution phenyl carbamothioyl) biphenyl-4-carboxamide derivatives have been prepared by first making biphenyl carbonyl isothiocyanate from ammonium thiocyanate and biphenyl carbonyl chloride, and then treating this products with primary amine to give products monothiourea, N- (phenylcarbanothioyl) biphenyl 4-carboxamide (1); N(p – tolylcarbmothoyl) biphelyl – 4 – carboxamide ( 2 ) and bisthiourea; N, Ã?â?¦Ã?Æ?(1,4- phenylenebis (azanediyl) bis (thioxo methylene) dibiphenyl-4-carboxamide(3)and N,Ã?â?¦Ã?Æ?(1,2-phenylene bis (azanediyl) bis (thioxo methylene) dibiphenyl-4-carboxamide (4). The structures of these compounds was characterized spectroscopy, theoretically and biological activity; the anti-bacterial activity indicated that compounds possessed a broad spectrum of activity.
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