Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization, biological evaluation and docking studies of organo phosphorous pyrazole5-one derivatives of Isatine Mannich bases derivatives of sortase A staphylococcus inhibitors
Author(s): N. Sandhya Rani, G. V. Subbareddy, K. N. Jayaveeera, L. K. RavindranathNew novel derivatives of diethyl2((4R)-4-(diethylphosphoryl) (phenyl/4-methoxy/4-triflouromethyl/4-nitrophenyl amino)methyl)-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl-)-N1-(1morpholine/thiazomorpholino methyl) -2-oxoindolin-3-yilidene)acetohydrazide(10a-h) containing various heterocyclic substituent’s were synthesized, characterized by elemental analysis,IR,1HNMR and 13CNMR spectra and evaluated for in antimicrobial and antifungal activity. Molecular docking studies were performed to calculate docking scores and to propose the binding mode of isatine mannich bases.
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Citations : 15261
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