Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Characterization and in-vitro Antimicrobial activity Studies of Co (II), Ni (II) and Cu (II) Complexes with ONSO Donor Coumarin Schiff Bases
Author(s): Shrishila N. Unki* and Shekappa D LamaniA series of Co(II), Ni(II) and Cu(II) complexes have been synthesized with Schiff bases derived from 3-substituted-4-amino-5-mercapto-1,2,4-triazole and 8-acetyl-7-hydroxy-4-methylcoumarin. The chelation of the complexes has been proposed in the light of analytical, spectral (IR, UV–Vis, 1H NMR, ESR and FAB-mass), magnetic and thermal studies. The measured molar conductance values indicate that, the complexes are non-electrolytic in nature. The redox behavior of the complexes was investigated with electrochemical method by using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for their in vitro antibacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal activities (Candida albicans, Cladosporium and Aspergillus niger) by MIC method.
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