Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Characterization and evaluation of Antibacterial Activity of some 3-Substitutedphenylquinazoline -2,4-diones
Author(s): Zaranappa, H M Vagdevi, N D Jayanna, K P LathaIn the present study a series of 3-substitutedphenylquinazoline-2,4-diones 1(a-m) have been synthesized from isatoic anhydride with substituted aromatic amines. The structure of these compounds has been established on the basis of their analytical and spectral data. All the compounds have been screened for their in vitro antibacterial activity at MIC level (minimum inhibitory concentration) against Bacillus subtillis, Staphylococcus aureus, Escherichia. coli, and pseudomonas aeruginosa. Most of the synthesized compounds showed promising antibacterial activity compare to the standard drug ciprofloxacin.
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