Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Characterization and Biological Activity Study of Some New Compounds Containing Amine and Azomethine Group and their Platinum II Complexes
Author(s): Bushra K. Al-Salami, Ahmed L. Al-Fadhly and Adil A. Al-FregiNew platinum (II) complexes were synthesized from two types of amine compounds as Ligands. The first type derived from the reaction of ethylenediamine with 3-phenylpropylbromide with molar ratio [1:1] and [1:2] respectively , the other type was new Schiff base derived from condensation of o-phenylenediamine with [ 2- furaldehyde, ferrocenecarboxaldehyde and acetyl ferrocene ] with different molar ratio [ 1:1 and 1:2 ]. The ligands and their platinum (II) complexes were characterized by FT-IR , UV-Vis , 1H-NMR and CHN elemental analysis . The spectroscopic analysis results demonstrate that the coordination sites are the nitrogen atom of NH2 groupor the azomethine nitrogen atom of the Schiff base . The conductivity values between 3.00 – 7.70 ohm-1.cm-1.mol-1in DMSO imply the presence of non-electrolyte species. With the help of different spectral like IR , UV-Vissible , 1H-NMR , CHN the geometrical structure of the complexes was proposed to be a square planar . Antibacterial activity of synthesized amino compounds and their complexes were tested against Staphylococcus aureus (+ev) gram and Escherichia coli (-ev) gram . The DNA cleavage activity of the complexes were assayed using UV-Vis spectrum. The result shows that there was overlap between the complexes and human DNA.
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