Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis, characterization and biological activity of novel spiroheterocycles from isatin derivatives
Author(s): RamuP, Augustine Arul Prasad T, Scholastica Mary Vithiya, S. Arul AntonyReaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivative (6), dehydration of (6) gave 3-phenacylidene-2-indolinone derivative (7). Reaction of (7) with sarcosine and acenaphthenequinone yield novel spirooxindole derivatives which are characterized by various spectral methods. The compounds were subjected to antibacterial and antifungal studies and the results are very promising.
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Citations : 15261
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