Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization and antimicrobial activity of spiro-
Author(s): A. Zahir Hussain, M. Nagoor Meeran and A. SankarIn the present study, a series of 5–fluro and 5–Iodo indole–2,3–dione based spiro–4–thiazolidiones was synthesized, characterization and evaluated for their antimicrobial activity. Condensation of 5–fluro and 5–Iodo indole–2,3–dione with substituted primary aryl amine to give a Schiff bases (A05, A06) which on reaction with thioglycolic acid and thiolactic acid in 1,4-dioxane afforded the formation of the corresponding 4-thiazolidinones (D05, D06, E05 and E06). All the synthesized compounds were characterized on the basis of their IR, 1H and 13C NMR and elemental analysis. The antimicrobial activity of all the compounds (A05, A06, D05, D06, E05 and E06) showed significant activity against all the bacteria and fungus.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
