Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization and antimicrobial activity of some novel s-triazine derivatives incorporating quinoline moiety
Author(s): N. Kavitha a , A. Arun b and S. Syed Shafi *This paper discuss a series of s-Triazine derivativ es based quinoline demonstrate a wide range of biol ogical activity.In the present investigation 4,7 –dichlor oquinoline as taken as starting material and treate d with ethylene diamine afforded 4-substituted 7-chloroquinoline,Wh ichfurther reacted with 1,5-disubstituted cyanuric chloride yielded 1,3,5-triazine chloroquinoline derivatives. All the synthesized compounds were characterized us ing IR ,H 1, C 13 NMR, mass spectral studies and elemental analysis. The final compounds were screened for their anti bacterial activity using E.coli,S-aureus and S.typh i and antifungal activity.
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Citations : 15261
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