Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization and antimicrobial activity of some novel isoindole-1,3-dione derivatives
Author(s): Kamelia M. Amin, Afaf H. El-masry, Neama A. Mohamed, Ghada E. A. Awad and Basma S. HabibThe present investigation, represents the synthesis of new derivativescontaining2-((4-acetyl phenyl amino)methyl)isoindoline-1,3-dione moiety incorporated with different heterocycles such as pyrazoline, isoxazoline, pyrimidine, pyridones and iminopyridine. Spectral techniques of IR, 1H NMR, Mass spectroscopy and elemental analyses were used to characterize the synthesized compounds.Most of the synthesized compounds were tested for their antimicrobial activity against a variety of gram positive and gram negative bacteria as well as fungal isolates using Ciprofloxacin and Ketoconazole as reference drugs. Some of the tested compounds showed potent activity and could be considered as promising antibacterial and antifungal agents.
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Citations : 15261
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