Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization and antimicrobial activities of N-substituted indoline derivatives of sultams
Author(s): S. Harikrishna and L. K. RavindranathA new class of N-Substituted Indoline derivatives of Sultams namely (E)-2-benzyl-N'-(N-Substituted-2-oxoindolin-3- ylidene)-3-phenyl-2,3,4,5-tetrahydrobenzo[f][1,2,4]thiadiazepine-5-carbohydrazide 1,1-di oxide (10-12) were synthesized through a process of mannich reaction where hydrazone derivative of Sultam (9) get reacted with pipperidine, Morpholine and Methylpipperazine to afford the title compounds. The structure of each novel compound was elucidated on the basis of elemental analysis, IR 1H NMR and Mass spectral Analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that the pharmacological properties of the synthesized compounds were enhanced by introducing pipperidine, Morpholine, Methylpipperazine substituents.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
