Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterization and antihyperlipidemic activity of novel condensed pyarazolo [3,4-d]pyrimidine derivatives
Author(s): Samrat A. Khedkar, Pratibha B. AutiIn the present study, a novel series of 4,6-disubstituted-3-(methylthio)-1-phenyl-1-H-pyrazolo[3,4-d]pyrimidines were synthesized using appropriate synthetic route. Newly synthesized compounds were characterized using spectral data (IR, 1H NMR and mass spectrometry) and were evaluated for their antihyperlipidemic activity. Hyperlipidemia was induced in animal models like Wistar albino rats by using Triton WR 1339 model and antihyperlipidemic activity was evaluated with respect to the percentage reduction in total serum cholesterol levels, percentage reduction in serum triglycerides levels, percentage change in serum HDL levels.
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Citations : 15261
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