Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterisation and antimicrobial activity of novel substituted pyrimidines
Author(s): Priti U. Warbhe andReshal A. DeshmukhNovel pyrimidine compounds were synthesised by condensation of substituted primary amine, ethyl acetoacetate and urea/ thiourea. This multicomponent reaction is of much importance due to excellent pharmacological properties of pyrimidines. On this account, we synthesized some substituted pyrimidines and their derivatives. Structures of these compounds were confirmed by 1H-NMR, 13C-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against standard strains of Gram positive and Gram negative bacteria using the Agar plate diffusion technique. Most of the studied compounds showed promising activities against gram positive and gram negative bacteria.
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