Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, characterisation and anti-breast cancer and antibacterial evaluation of novel 2-phenylquinoline amide derivatives
Author(s): Kailas W. Shinde*A series of new class of 2-phenylquinoline amide derivatives (5a-5j) were synthesized from 5-nitroquinoline through multi-step reactions in good to moderate yields. All the compounds were confirmed by spectral characterization viz FT-IR, MS, 1H-NMR and 13C-NMR. All the molecules were evaluated for their anticancer activity against a breast cancer cell line, MDA-MB-231 by MTT assay and antibacterial activity against Grampositive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using agar well diffusion method. All the compounds exhibited significant anticancer activity as compared to standard cisplatin but not comparable to doxorubicin HCl. Compound 5g exhibited better promising anti-breast cancer activity. Compounds 5d, 5h, 5i and 5j exhibited moderate antibacterial activity against all the tested organisms among all the synthesized analogues as compared to standard streptomycin. Based on the results, further modification and optimization of these compounds may be useful to develop potent anticancer and antibacterial drug.
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