Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide
Author(s): Mashooq A. Bhat, Mohammed A. Al-Omar, Nadeem SiddiquiA series of novel 1,3,4-oxadiazole derivatives of phthalimide (4a-j) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity studies. All the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4j having methoxy substitution at para position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.
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