Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and structural studies of Glucosylimino-1,2,4,5-Tetrazine
Author(s): B. N. Berad, S. M.Bhiwagade and A. G. UlheSeries of 3-tetra-O-acetyl–β-D-glucopyranosylimino, 6 substituted -1,2,4,5-tetrazine (IV) have been synthesized by the reaction of aryl dihydroformazanes (III) and tetra-O-acetyl-β-D-glucosylimino-isocyanodichloride in refluxing chloroform medium. The aryl dihydroformazans (III) were prepared by the interaction of acid hydrazides (I) and hydrazine hydrate (II) in refluxing ethanol medium in 1:1 proportion. The structures of tetrazines (IV) were confirmed on the basis of elemental analysis and IR, PMR, 13C and mass spectral analysis.
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