Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and pharmacological screening of some novel chloro chalconesemicarbazone derivatives
Author(s): Hemendra Pratap Singh, C S Chauhan, S N Pandeya, C S Sharma, B Srivastava, Manmohan SinghalA series of chalconyl derivatives of chloro phenyl semicarbazide (CA1-CA5) was synthesized. All the synthesized compounds were screened for their pharmacological action in protection of seizures, behavioral study, anti-inflammatory and analgesic activity. After intraperitoneal injection to mice or rats, the synthesized compounds were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), and neurotoxicity test models. Compound CA6 emerged as the most active molecule for anticonvulsant and anti-inflammatory activity. Some of the title compounds exhibited lesser CNS depression compared to phenytoin as was evident from the CNS studies
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Citations : 15261
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