Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.
Abstract
Synthesis and Pharmacological Screening of New Thienopyridines for the treatment of Alzheimer�¢����s disease
Author(s): Afaf El-Malah, Zeinab Mahmoud and Mai A. AbdEl FattahAlzheimer is a multitargeting brain-hitting disease. The need to prepare and screen new agents is endless. Novel thienopyridine-tacrine analogues 4a,b – 8a,b and 9 have been designed, synthesized and biologically screened against cholinesterase inhibition activity. Two compounds 7a and 7b were found active. Compound 7b exceeded tacrine as a cholinesterase inhibitor. The docking studies explained this activity as compound 7b exhibited similar binding affinity to the acetylcholinesterase enzyme as with tacrine in addition to an extra hydrogen bonding
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
