Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and molecular modeling of new quinoline derivatives as antitumor agents
Author(s): Lamiaa Osama, Laila A. Abou-Zeid, Magda N. A. Nasr and Atif S. TantawyA new series of quinoline containing compoundswasdesigned,synthesized and evaluated biologically for their invitro
antitumor activity. Compounds 7, 8,11, 12,17 and 18showed the best cytotoxic activity against five tumors cell lines
(HePG-2, HCT-116, MCF-7, PC3 and Hela) with IC50 range between 5.6-19.2 μg/ml. Molecular modeling studies
have been performed for the investigated compounds to evaluate their recognition profiles at the VGFR tyrosine
kinase binding-pocket.
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Citations : 15261
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