Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and microbial studies of imidazolone based azetidinone analogues
Author(s): Snehal Lokhandwala and Nikhil M. ParekhIn the present study we have reviewed the synthesis and different biological activities of some azetidinone derivatives. A series of new azetidinone class of bioactive agents based on imidazol-4-one nucleus have been synthesized by a simple and efficient synthetic protocol. The 3-(4-amino-phenyl)-5-benzylidene-2-methyl-3,5- dihydro-imidazol-4-one nucleus formed from 4-benzylidene-2-methyl-4H-oxazol-5one using p-phynelenediamine in pyridine followed by reaction with various substituted aromatic aldehyde to form the corresponding Schiff base intermediates. Effort has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride. Newer analogues were characterized by IR, 1H NMR, and elemental analyses. The newly synthesized analogues were then examined for their antimicrobial activity against some bacterial and fungal strains to develop a novel class of antimicrobial agents.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
