Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and Microbial Screening of (2-Propyl-Benzimidiazole-1-yl) Acetic Acidbenzylidene Hydrazide
Author(s): Maqdoom Farooqi, Syed NazimuddinIn the present work, a simple convenient and high yielding synthetic route has been employed for the synthesis of targeted molecules (2-propylbenzoimidazol- 1-yl)-acetic acid benzylidene-hydrazid (1a-d) and 4-(Benzylidene-amino)-5-(2-propyl-benzoimidazol-1-ylmethyl)-4H- [1,2,4]triazole-3-thiol(2a-d). The structures were confirmed by Fourier Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (H1NMR) and physical properties. The synthesized compounds were screened for anti-microbial analysis against Bacillus subtilis, Staphylococcus aureus, Candida albicans and Escherichia coli, Aspergillus niger. The compounds are found to be highly active, hence forth, could be attractive lead molecules for developing new therapeutics against tested microorganisms.
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Citations : 15261
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