Synthesis and evaluation of new pyrazoline and thiazolidinone derivatives as anticancer activity

Jalal H. Abdullah; Tawfeek Ahmed Ali Yahya; Mokhtar Abd Hafiz Al-ghorafi; Shada H. Yassin

Abstract

Synthesis and evaluation of new pyrazoline and thiazolidinone derivatives as anticancer activity

Author(s): Jalal H. Abdullah, Tawfeek Ahmed Ali Yahya, Mokhtar Abd Hafiz Al-ghorafi, and Shada H. Yassin

Three new series of (2 -{ 4- [3 -(4-substituted-phenyl)-acryloyl]-phenylimino}-4-oxo-3-substituted- thiazolidin-5- yl)-acetic acid (2a-c), (2-{4-[5-(4-substituted-phenyl)-1H-pyrazol-3-yl]-phenylimino}-4-oxo-3-substitutedthiazolidin- 5-yl)-acetic acid. (4a-i ), and (2-{4-[5-(4-substituted-phenyl)-1-hydrazinothiocarbonyl-4,5-dihydro-1Hpyrazol- 3yl]-phenylimino}-4-oxo-3-substituted-thiazolidin-5-yl)-acetic acid (5a-i) were synthesized. Reaction of compound ( 1 ) with maleic anhydride afforded (2), The latter was condensed with aromatic aldehydes to afford compounds (3). Treatment of compound (3) with hydrazine hydrate or thiocarbohydrazide resulted in the formation of (4), and (5) respectively. The purity of all new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1HNMR, the target compounds were evaluated for their anticancer activities in comparison with, doxorobicin as reference drug.

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