Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and evaluation of anti-inflammatory and antimicrobial activity of 2,5-disubstituted-1,3,4-oxadiazoles
Author(s): Pooja Chawla, Radhika Maheshwari and Shubhini A. SarafIn the present study two new series of [5-(4-substituted-phenyl)-[1,3,4]oxadiazol-2-yl]-pyridine (1a-1d) and 2-(4-substituted phenyl)-5-(2-aminophenyl)-1,3,4-oxadiazole (2a-2e) were synthesized from esters and hydrazine hydrate in the presence of ethanol through isonicotinic acid hydrazide and 2-aminobenzohydrazide respectively followed by reaction with phosphorus oxychloride and various aromatic acids. Synthesized compounds were subjected to antiinflammatory and antimicrobial activity. A fair number of compounds were found to have good anti-inflammatory activity in carrageenan-induced rat paw oedema test, while all the compounds showed significant antibacterial activity.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
