Abstract

Synthesis and Evaluation of Antifungal Activity of N-Methyl-2-α-[(N4-Aryl) Piperazin-1-yl] Ethyl Benzimidazoles

Author(s): Pardesi VN, Jagdale AS, Wani RD, Wagh SB, Patankar RD

The relative broad spectrum of activity of the azoles against common fungal pathogens, ease of administration and limited toxicity are highly attractive features. Antifungals work by exploiting differences between mammalian and fungal cells to kill off the fungal organism without dangerous effects on the host. Benzimidazoles and piperazines are the important pharmacophores in the field of medicinal chemistry, due to their widespread pharmacological activities, so to exploit their antifungal potential we have selected these two for our research work but they have several drawbacks and limitations like adverse drug reaction due to co-administration and occurrence of resistance of fungal organisms, especially Candida species, to fluconazole. These limitations of the azoles will become more problematic if fluconazole and other azoles continue to be used injudiciously. Many benzimidazole derivatives substituted with piperazines have been synthesized and evaluated for antifungal activity in our department. From the above limitations benzimidazole containing antifungal agents, we have synthesized different substituted aryl piperazines, N-methyl-2-[α-(chloro) piperazin-1-yl] ethyl benzimidazole nucleus, condensed it to offer targeted compounds, evaluated the structures of targeted compounds on the basis of Infra-red spectra, NMR spectra and mass spectra and further carried out antifungal activity against Candida albicans.

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