Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and evaluation of 4-aryl-2-[(2E)-2-substituted hydrazinyl]-1,3- thiazoles for possible antioxidant and antimicrobial activities
Author(s): Prajwal L. Lobo, Boja Poojary, K. Manjunatha, N. Chidananda, Vinaya Chandra, N. Suchetha KumariIn the present work 4-aryl-2-[(2E)-2-(3,4,5-trimethoxybenzylidene)hydrazinyl]-1,3-thiazoles and 4-aryl-2-{(2E)-2- [5-phenylfuran-2-yl)methylidene}hydrazinyl}-1,3-thiazoles were synthesized in good yield by cyclisation of the corresponding thiosemicarbazones with substituted phenacyl bromides in alcohol media. The thiosemicarbazones were in turn prepared by treating aryl aldehydes /arylfurfuraldehydes with thiosemicarbazide in the presence of few drops of sulphuric acid in alcohol media. The structures of newly synthesized compounds were characterized by the spectral studies. The newly synthesized compounds were evaluated for their anti-microbial and antioxidant activity. From the biological studies, it was possible to observe that some of the substituents on the phenyl ring influenced the activity. Among synthesized compound 2b, 4a and 4f have shown very good antioxidant activity when compared the reference drug. Compounds showed moderate to good antimicrobial activity at low concentration.
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