Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and characterization of Tenofovir disoproxil fumarate impurities, anti HIV drug substance
Author(s): Dipak Varal, Mandar Joshi, Deepak Panmand and Vidyadhar JadhavIn the process development of Tenofovir disoproxil fumarate specified known, specified unknown and unidentified impurities found. The present work describes synthesis and characterizations of USP related known and unknown impurities; mono-POC Tenofovir (5), mono-POC methyl Tenofovir (6a), mono-POC ethyl Tenofovir, (6b), mono- POC isopropyl Tenofovir (6c), Tenofovir isopropyl isoproxil (7) and Tenofovir disoproxil carbamate (9). Identification of these impurities can be useful for quality control purpose in the manufacture of Tenofovir disoproxil fumarate.
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