Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and Characterization of Novel Chalcones of 3-Benzylidene-2-chlorocyclohex-1-enecarbaldehyde as Potential Anti-proliferative Agents
Author(s): Kathiravan PR, Muthukumaran S, Dhatchanamoorthy N, Prince AAM, Venugopal MA series of novel chalcones of 3-Benzylidene-2-chlorocyclohex-1-enecarbaldehyde were synthesized by reacting benzylidene derivative of chloro aldehyde with different aromatic and heterocyclic ketones. All the synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and Mass spectra. The synthesized compounds were evaluated for their in vitro cytotoxicity. In particular, the compounds of the series 5 and fluorinated compounds of 5-9 exhibited superior cytotoxic property.
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Citations : 15261
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