Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and characterization of N-(4-(4-chlorophenyl)-6-(3,4- dimethylphenyl)pyrimidin-2-yl)-4-(2,6-diphenyl-4-thioxo-2H-1,3,5-oxadiazin-3(4H)-yl)benzenesulfonamide
Author(s): Rambabu Nunna and Viral B. Modi, Kirti J.Goswami4-Amino-N-[4-(4-chloro-phenyl)-6-(3,4-dimethyl-phenyl)-pyrimidin-2-yl]- benzensulfonamide (2) was prepared by the hydrolysis of N-{4-[4-Chloro-phenyl}-6-(3,4-dimethyl-phenyl)-pyrimidin-2- ylsulfamoyl]-phenyl}-acetamide (1).It was on-facile condensation reaction with various aromatic aldehydes yields Schiff bases /anils/azomethines (3a-h). These anils on cyclo addition reaction with benzoyl isothiocyanate afforded 1,3,5-Oxadiazine (4a-h). The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
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