Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and characterization of imidazo[1,2-b]pyridazine linked thiazolidin amides
Author(s): Sudugu Ramakrishna Reddy, Ch. Venkata Ramana Reddy and B. SatyanarayanaIntroducing thiazolidin moiety into the imidazo[1,2-b]pyridazine ring which leads to the presence of three active pharmacophores in a single molecular frame work for the intensified biological activity. A variety of novel imidazo[1,2-b]pyridazine-2-carboxylic acid (4-oxo-2-phenyl-thiazolidin-3-yl)-amides have been synthesized in good to excellent yields. The title compounds were obtained from commercially available imidazo[1,2-b]pyridazine-2- carboxylic acid as starting compound and imidazo[1,2-b]pyridazine-2-carbonyl chloride, imidazo[1,2-b]pyridazine- 2-carboxylic acid hydrazide and imidazo[1,2-b]pyridazine-2-carboxylic acid benzylidene-hydrazide as integral part of the synthesis.
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