GET THE APP

Synthesis and biological evaluation of some novel 1,2,4-triazole derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and biological evaluation of some novel 1,2,4-triazole derivatives

Author(s): Dharmesh S. Dayama, Pravin N. Khatale, Samrat A. Khedkar, Swapnil R. Nazarkar, Prasad A. Vedpathak

In order to search novel antimicrobial and antifungal agent series of new 5-phenyl-1-H-1,2,4-triazol-3-thione derivatives bearing different aldehydes moieties were designed and synthesized through multistep reactions. The newly synthesized compounds were evaluated for in vitro antibacterial activity against S. aureus, E. species, E. coli, P. auriginosa, and antifungal activity against A. niger, C. albicans using broth micro dilution method. Ciprofloxacin and Fluconazole were used as standard for antibacterial and antifungal screening respectively. Among the compounds 4a-4f, particularly, compound 4b and 4d showed highest antibacterial activity as compared to the other derivatives against all bacterial species with a MIC of 200 μg/ml. Compound 4d emerged as the most effective antifungal agent against C.albicans and A.niger.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry